Which of the foll A. It cannot be treated with iron supplements

B. It is a molecular disease

C. It confers resistance to acquiring malaria

D. All of the above

Sickle cell anaemia is a genetic disorder in which Valine is substituted instead of Glutamic Acid in the beta Haemoglobin chain.This mutation leads to the change of RBC’S shape from disc shape to sickle like shape leading to decreased oxygen in the body.

a) As it is a genetic disorder it cannot be treated with iron supplements.

b) The substitution of valine instead of Glutamic Acid in the beta Haemoglobin chain shows it is a molecular disease.

c) Individual who has only one sickle cell mutation gene that is from either mother or father and not from both, the person will not inherit the disorder but would get the sickle cell trait .This trait is protective against malaria.

This shows all the above statements stands correct.