Q. 91

Note: In the following questions a statement of assertion followed by a statement of reason is given. Choose the correct answer out of the following choices.

Assertion : Competitive inhibitors compete with natural substrate for their attachment on the active sites of enzymes.

Reason : In competitive inhibition, inhibitor binds to the allosteric site of the enzyme.

A. Assertion and reason both are correct statements and reason is the correct explanation for the assertion.

B. Assertion and reason both are correct statements, but the reason is not the correct explanation for the assertion.

C. The assertion is a correct statement, but the reason is the wrong statement.

D. Assertion and reason both are incorrect statements.

E. The assertion is a wrong statement, but the reason is the correct statement.

Answer :

Competitive inhibitors (drugs) compete with the natural suitable substrates for their attachment of on the active sites of enzymes.


These kinds of drug block the binding active site of the enzyme & somehow prevents the linkage b/w enzyme & substrate inhibiting the natural catalytic activity of the enzyme.


The reason statement, here is wrong because only non-competitive inhibitors ( different than competitive drugs) bind to a different site than the active site which is called the allosteric site of an enzyme resulting a change of shape in the active site of that enzyme in such a way it becomes impossible for the substrate to identify the active site and to bind to it.


Thus these type of inhibitors (non-competitive) do not directly deal with the active site of the enzyme.



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