DNA-dependent DNA polymerase is responsible for nucleotide polymerisation in DNA replication.
Characteristic features of DNA polymerase:
a. Highly efficient:
These enzymes are highly efficient enzymes as they have to catalyse polymerisation of a large number of nucleotides in a very short time.
b. Highly accurate:
Not only do these polymerases have to be fast, but they also have to catalyse the reaction with high degree of accuracy. They also have the proof-reading capacity, which increases the accuracy of DNA sequence replication. High-fidelity DNA polymerases are enzymes with strong proofreading activity.
In E. coli, this enzyme can initiate replication in a specific region called “origin of replication”.
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