Most often during a kidney disorder, the colour of urine changes from yellow to others. A patient is secreting dark coloured urine which turns to blue or black later. This is due to the presence of which of the following?
A. Homogentisic acid
D. Both A and B
The accumulation of Homogentisic acid (phenolic acid) causes alkaptonuria (a rare inherited disease that causes the urine to turn black when comes in contact with air). This accumulated acid is excreted out in urine giving it a dark colored appearance. Alkaptonuria is caused by the deficiency of an enzyme (homogentisic dioxygenase).
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